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New Dual Alzheimer’s Trials Aim for Early Detection & Slow Progression

July 22, 2025

Key Takeaway

NIH’s CARD expands diverse genetic studies and biomarkers for early Alzheimer’s detection while a Georgia trial tests vitamin B1 to slow cognitive decline.

A 2023 Yale study found that 78% of Connecticut’s average 31 annual heat-related deaths occur in adults aged 65 and older.

Columbia’s Dr. St-Onge’s 28-day cookbook and Meritus Food Farmacy aim to improve sleep and heart health for seniors through tailored nutrition.

Massachusetts orders comprehensive fire safety audits and egress protocols for 273 assisted living facilities after the Gabriel House fire.

Two dogs trained on sebum-rich skin swabs detected Parkinson’s with 80% sensitivity and 98% specificity in double-blind tests.

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Dual Alzheimer’s Efforts Boost Early Detection and Slow Progression

Two-pronged push: Federal scientists and Georgia clinicians are racing to tackle Alzheimer’s on two fronts: early detection and slowing its march.

• NIH’s CARD Initiative is mining diverse genetic data, creating stem‐cell and organoid models, and deploying proteogenomic pipelines to spot biomarkers before symptoms strike.

• Emory‐led Georgia trial is enrolling adults 50–89 in an 18-month, double-blind study to test whether vitamin B1 can meaningfully slow cognitive decline.

Together, these efforts aim to catch Alzheimer’s earlier and give families new tools to manage its progression.

Rising Summer Heat Presents Serious Risks for Seniors

Summer’s mounting heat waves and rising nighttime lows are putting older adults in the U.S. at heightened risk. In Florida, internal medicine physician Dr. Gary Hardoon reports a surge in preventable heat-related illnesses—from muscle cramps to life-threatening heat stroke—especially among seniors on medications like diuretics or beta blockers.

In Connecticut, 2025 is on track for the third-warmest summer nights on record in Hartford, with average overnight lows up over 2°F since 1990. A 2023 Yale study found that adults 65+ account for 78% of the state’s 31 annual heat-related deaths, underscoring the cumulative toll of persistently high day-and-night temperatures.

Experts advise proactive hydration, lightweight clothing, early-morning or evening activities, and using air conditioning or cooling centers to stay safe.

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New Nutrition Initiatives Boost Senior Sleep and Heart Health

Columbia University nutrition researcher Marie-Pierre St-Onge and Meritus Health have launched two complementary programs to help Americans aged 65 and older harness the power of food for better sleep and cardiovascular wellness. St-Onge’s new 288-page cookbook, Eat Better, Sleep Better, features a 28-day meal plan with 75 recipes rich in tryptophan, omega-3 fatty acids and complex carbs—nutrients linked to melatonin and serotonin production.

Meanwhile, Meritus Health’s pilot Food Farmacy prescribes up to $50 worth of condition-specific groceries weekly, plus recipes, cooking demos and dietitian visits, to address malnutrition and chronic diseases such as diabetes and heart disease. Both efforts reflect an evidence-based shift toward using diet as medicine—a move supported by the American Heart Association’s inclusion of sleep in its Life’s Essential 8 and by CDC data showing nearly 40% of U.S. adults lack sufficient rest.

Massachusetts Mandates Safety Overhaul for Assisted Living After Fall River Fire

Massachusetts Governor Maura Healey has directed an immediate, statewide safety review of all 273 assisted living residences after a July blaze at the Gabriel House in Fall River killed ten residents. The Executive Office of Aging and Independence will require each facility to:

Send detailed fire‐safety letters to residents and families

Post evacuation routes and key contacts in every unit

Complete a standardized fire safety assessment within 30 days

State officials say these measures will strengthen emergency readiness and ensure compliance with sprinkler, drill and door‐maintenance standards across the sector.

Dogs Accurately Detect Parkinson’s via Skin Swabs

Dogs detect Parkinson’s with 80% sensitivity and 98% specificity after weeks of training on over 200 sebum-rich skin swabs, reports a University of Bristol-led study in the Journal of Parkinson’s Disease. Two canines—Bumper the Golden Retriever and Peanut the Labrador—successfully flagged samples from patients with confirmed Parkinson’s in double-blind trials.

This approach hinges on an excess sebum odor signature, emerging years before visible motor symptoms. Researchers say such a non-invasive, cost-effective screening could accelerate early diagnosis for older adults, enable prompt treatment planning, and reduce progression risk. Medical Detection Dogs and the University of Bristol aim to expand trials and refine protocols for clinical use.

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